![]() ![]() Thus we will use fly as a discovery tool, to identify genetic pathways important for neural degeneration, regeneration and tumorigenesis, and assess their evolutionary conservation in vertebrates. We further plan to adopt the rodent motor neuron degeneration, glaucoma and traumatic brain injury models. We have experience with the fly neurodegeneration model, the rodent optic nerve crush and spinal cord injury models. ![]() We and collaborators have been utilizing and generating fly brain tumor models. We have established the Drosophila sensory neuron degeneration and regeneration model, and have recently developed a second Drosophila CNS injury model. ![]() Our lab builds on a platform to take advantages of the power of fly genetics in discovering novel factors together with the mammalian injury models to study their homologs and functional recovery. What is also lacking is a systematic way to dissect the pathways underlying the four steps of axon regeneration, namely degeneration/debris clearance, regrowth, overcoming the hostile environment and re-building connectivity.Ĭross-species and multi-model analyses to map the gene circuits critical for maintaining nervous system function Currently, only a few therapies with limited efficacy are available, highlighting the urgent need to identify novel molecular targets and develop targeted therapies. Under pathological situations such as multiple sclerosis (MS), the second most common neurological disorder leading to disability in young adults, the failure of damaged axons to regenerate contributes to non-reversible neurologic dysfunction. ![]() Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesisĭamage to the adult CNS, such as spinal cord injury (SCI) often leads to persistent deficits due to the inability of mature axons to regenerate after injury. With a background in neural development, neural circuits and behavior, fly and mouse genetics, injury and neurodegeneration models, our lab offers a unique skillset and perspective for addressing physiological questions in developmental/functional neurobiology and neurological diseases. The long-term goal of the Song lab is to elucidate the cellular and molecular basis governing the formation, maintenance and function of neural circuits under physiological and pathological conditions, using both Drosophila and mammalian models. ![]()
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